Burning mouth syndrome (stomatodynia) sensile to duloxetine-a case report

  • T. Saranya Pharm D, Department of Pharmacy Practice, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.
  • A. Heena Kauser Pharm D, Department of Pharmacy Practice, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.
  • Robin George Department of Pharmacy Practice, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.
  • E. Sunil Kumar Department of Pharmacy Practice, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.
Keywords: Clonazepam, Serotonin, Burning Mouth Syndrome, Duloxetine

Abstract

Introduction. Burning mouth syndrome (BMS) is a chronic, idiopathic, intraoral mucosal pain condition in the absence of specific oral lesions and systemic disease. Among evidence-based pharmacological treatments for this disorder, topical and systemic clonazepam, levosulpiride, selective serotonin reuptake inhibitors have been used with partial results.

Case: We report a case of a 65-year-old healthy woman with a 3-year history of oral burning.

Clinical and laboratory evaluations allowed us to make a diagnosis of burning mouth syndrome. She was treated with duloxetine [DLX]  (60 mg PO qd), a selective serotonin, and norepinephrine reuptake inhibitor, obtaining a complete remission of symptoms, evaluated via standardized clinical rating scales [BPRS], and an improvement of her quality of life and level of functioning.

Discussion: The pathogenesis of BMS still remains unclear. Recently, it has been suggested an underlying neuropathic mechanism, demonstrating a dysfunction in the trigeminal nociceptive pathways at peripheral and/or central nervous system level. The rationale behind the administration of duloxetine resides in its central mechanism of action, and analgesic effects previously demonstrated in diabetic peripheral neuropathy, and fibromyalgia. Also, it has been shown to reduce painful physical symptoms associated with depression.

Conclusion: We hypothesize that duloxetine might represent a useful, effective, and additional therapeutic option in the treatment of BMS.

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Published
20-05-2020
How to Cite
T. Saranya, A. Heena Kauser, Robin George, & E. Sunil Kumar. (2020). Burning mouth syndrome (stomatodynia) sensile to duloxetine-a case report. International Journal of Research In Pharmacovigilance and Pharmacotherapeutics, 1(1), 10-12. https://doi.org/10.33974/ijrpp.v1i1.193
Section
Case Reports

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