Conceptualization of cross-linking polymers and lipids for better bio adhesion and oral bioavailability

Abstract

Over the last decades, approaches in designing several lipid carriers have been evolved to deliver the poorly soluble drugs. Lipid based systems can play a vital role in improving the efficacy and safety, thus finally enhancing the therapeutic efficiency. LBDS can be modified in several ways to meet the wide range of product necessities as per the disease condition, product stability and route of administration. Crosslinking of polymers or lipids using modern techniques have greatly helped to modulate the specific release of drugs and as well safe guard the drug from various enzymes produced in the body thereby increasing the bioavailability greatly. The cross-linking will greatly enable to swell and even allow these varieties of polymers to adhere to the natural human tissues, mucosal membranes allowing them to be used for site specific release. The review emphasis on different approaches of crosslinking employed for complementing to prepare novel drug delivery systems like Emulsions, vesicular system and lipid particulate systems.