Formulation and evaluation of matrix tablets of Eperisone hydrochloride

  • Peruboina Neelima Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-34, Andhra Pradesh, India.
  • Maddula Venkata Ramana Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-34, Andhra Pradesh, India.
Keywords: Eperisone Hydrochloride, HPMC K100M, EC, PVP K30, in vitro drug release

Abstract

The aim of the present research is to develop and optimize Eperisone Hydrochloride extended release matrix tablets. Eperisone Hydrochloride is an antispasmodic drug mainly used to relieve pains it acts by relaxing the skeletal and smooth vascular muscles by blocking spinal reflexes drug which has oral bioavailability of 70% due to hepatic metabolism. Sustained release matrix tablets of Eperisone Hydrochloride were prepared through wet granulation technique by using HPMC K4M and EC as polymers, PVPK30 as binder, Magnesium stearate as lubricant and Talc as glidant. The granules of different formulations were determined for pre compression parameters. The prepared granules along with the excipients were then compressed. The formulated tablets were evaluated for physical characteristics viz. Hardness, Thickness, % Weight variation, Friability and the drug content. Furthermore the tablets evaluated for the in vitro release studies. Out of all the 8 formulations F7 showed desired characteristics in the physical parameters and in vitro drug release of 85.48% in 12hrs.The F7 dissolution data was best fitted to the Zero order model. The prepared Eperisone Hydrochloride matrix tablets found to be having a potential extended drug release.

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Published
05-07-2020
How to Cite
Peruboina Neelima, & Maddula Venkata Ramana. (2020). Formulation and evaluation of matrix tablets of Eperisone hydrochloride. International Journal of Research in Pharmaceutical Sciences and Technology, 1(4), 131-136. https://doi.org/10.33974/ijrpst.v1i4.203
Section
Research Article