Analytical method development and validation for the estimation of Mirabegron in pure and its solid dosage form by UV spectrophotometric method

  • Badike Kuruva Suresh Department of Pharmaceutical chemistry, College of pharmaceutical sciences, Acharya Nagarjuna University, Guntur, India, 2019.
  • Nerusula Anusha Department of Pharmaceutical chemistry, College of pharmaceutical sciences, Acharya Nagarjuna University, Guntur, India, 2019.
  • Anne Boyina Sravani Department of Pharmaceutical chemistry, College of pharmaceutical sciences, Acharya Nagarjuna University, Guntur, India.
Keywords: Mirabegron, 1N Hcl, UV Spectrophotometry, Betmiga

Abstract

A simple, economical, rapid, accurate, precise spectrophotometric method has been developed and validated according to ICH Guidlines for the Mirabegron as active pharmaceutical ingredient (API) by UV spectrophotometric method. The absorption maxima of Mirabegron was found to be at 249 nm wavelength using 1N Hcl as a solvent. Linearity range was found to be 3-15μg/ml, with the correlation coefficient being more than 0.999. The relative standard deviation was found to be < 2%. The percentage recovery was within the range of 98% -105%, indicating that there is no significant interference from the other ingredients present in the formulation. The method can be applied for the routine analysis of Mirabegron as API in pharmaceutical preparation.

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Published
20-07-2020
How to Cite
Badike Kuruva Suresh, Nerusula Anusha, & Anne Boyina Sravani. (2020). Analytical method development and validation for the estimation of Mirabegron in pure and its solid dosage form by UV spectrophotometric method. International Journal of Research in Pharmaceutical Sciences and Technology, 1(4), 146-150. https://doi.org/10.33974/ijrpst.v1i4.207
Section
Research Article