Formulation and in-vitro evaluation of ciprofloxacin HCl floating matrix tablets
Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form. Oral route is considered most natural, uncomplicated, convenient and safe due to its ease of administration, patient acceptance and cost-effective manufacturing process. Gastroretentive drug delivery system was developed in pharmacy field and drug retention for a prolonged time has been achieved. The goal of this study was to formulate and in-vitro evaluate Ciprofloxacin HCl controlled release matrix floating tablets. Ciprofloxacin HCl floating matrix tablets were prepared by wet granulation method using two polymers such as HPMC K100M (hydrophilic polymer) and HPMC K15M. All the Evaluation parameters were within the acceptable limits. FTIR spectral analysis showed that there was no interaction between the drug and polymers. In-vitro dissolution study was carried out using USP dissolution test apparatus (paddle type) at 50 rpm. The test was carried out at 37 ± 0.5 0C in 900ml of the 0.1 N HCl buffer as the medium for eight hours. HPMC K100M shows a prolonged release when compared to HPMC K15M. These findings indicated that HPMC K100M can be used to develop novel gastroretentive controlled release drug delivery systems with the double advantage of controlled drug release at GIT pH. On comparing the major criteria in evaluation such as preformulation and in vitro drug release characteristics, the formulation F8 was selected as the best formulation, as it showed the drug content as 99±0.4% and swelling index ratio was 107.14, and in-vitro drug released 61.31±0.65% up to 8 hours. Results indicated that controlled Ciprofloxacin HCl release was directly proportional to the concentration of HPMC K100M and the release of drug followed non-Fickian diffusion. Based on all the above evaluation parameters it was concluded that the formulation batch F8 was found to be best formulation among the formulations F1 to F8 were prepared.
2. Robinson Jr, Lee V.H.L, (1978). Controlled drug delivery: Fundamentals and Applications, 2nd edn. Marcel Dekker, New York, pp 24-36.
3. Brahmankar D.M, Jaiswal S.B, (1995). Biophar-maceutics and Pharmacokinetics a treatise, 1st ed. Vallabh prakashan; New Delhi, pp 64-70.
4. Chawla G, Gupta P, Koradia V, Bansal AK. Gas-troretention: A Means to address regional varia-bility in intestinal drug absorption. Pharm Tech 2003; 27: 250-268.
5. Singh BN, Kim KH. Floating drug delivery system: An approach to the controlled drug delivery via gastric retention. J Control Rel 2000; 63: 235-259.
6. Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: A review. Int J Pharm Res 2009; 1(3): 623-633.
7. Rouge N, Buri P, Doelkar E. Drug absorption sites in the gastrointestinal tract and dosage for site?specific delivery. Int J Pharm 1996; 136: 117-139.
8. Umamaheshwari RB, Jain S, Bhadra D, Jain NK. Floating microspheres bearing acetohyxamic acid for the treatment of Helicobactor pylori. J Pharm Pharmacol 2003; 55: 607-613.
9. Jain SK, Awasthi AM, Jain NK, Agrawal GP. Calci-um silicate based microsheres of repaglinide for gastroretentive floating drug delivery: Prepara-tion and in vitro characterization. J Control Rel 2005; 107: 300-309.
10. Cooper J, Gunn C. "Powder flow and compaction", In: Carter SJ, eds. Tutorial Pharmacy. New Delhi, India: CBS Publishers and Distributors; 1986; 211-33.
11. Shah D, Shah Y, Rampradhan M. Development and evaluation of controlled release diltiazem micro particles using cross linked poly (vinyl alcohol). Drug Dev Ind Pharm 1997; 23: 67-74.
12. Hadjiioannou TP, Christian GD, Koupparis MA. Quantitative calculations in pharmaceutical prac-tices and Research. New Delhi, NY: VCH publish-ers INC; 1993: 345-348.
13. Baumgartner S, Kristl J, Vrecer F, Vodopivec F, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int. J Pharm 2000; 195: 125-135.
14. Gergogiannis YS, Rekkas DM, Dallos PP, Chailis NH. Floating and swelling characteristics of vari-ous excipients used in controlled release tech-nology. Drug Dev Ind Pharm 1993; 19: 1061-1081.
15. Higuchi T. Mechanism of sustained action medi-cation? Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963; 52: 1145-1149.
16. Korsmeyer RW, Gurny R, Doelker E, Buri P and Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm 1983; 15: 25-35.
17. Siepmann J, Peppas NA. Modeling of drug release from delivery system based on hydroxypropyl methylcellulose (HPMC). Adv Drug Del Rev 2001; 48: 139-157.
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