Novel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs

  • Buduru Gowthami Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Y.S.R. Cuddapah, Dist-516126, Andhra Pradesh, India.
  • S.V. Gopala Krishna Department of Pharmacognosy, Vagdevi College of Pharmacy and Research Centre, Brahmadevam, Nellore-524001, Andhra Pradesh, India.
  • D. Subba Rao Professor, Department of Chemical Engineering, J.N.T.U.A Ananthapuramu-515002, Andhra Pradesh, India.
Keywords: Lipids, Polymers, Nanoparticles, Oral Bioavailability, Nanofibers, Nanoemulsions

Abstract

Oral administration is considered as major, convenient route among all other routes of delivery, owing to several benefits. But, the poor solubility or enzymatic/metabolic activity are the major concerns in developing a successful formulation. About 40% of approved drugs which are in the current market and 90% of new drug molecules in the developmental pipeline are hydrophobic in nature. The challenge to formulate insoluble drugs has met with various approaches to overcome the problems related to solubility, application of nanotechnology is one amongst them. The present review deals with various nanocarriers and technologies that are proven to be effective in enhancing the bioavilability of poorly soluble drugs.

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Published
17-09-2020
How to Cite
Buduru Gowthami, S.V. Gopala Krishna, & D. Subba Rao. (2020). Novel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs. International Journal of Research in Pharmaceutical Sciences and Technology, 2(1), 12-16. https://doi.org/10.33974/ijrpst.v2i1.231
Section
Review Article