Dendritic nanoparticulated carriers for the delivery of Rifampicin

Authors

  • B. Valli Manalan Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University) Salem – 636008 Tamil Nadu, India. Author
  • B. Arul Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University) Salem – 636008 Tamil Nadu, India. Author
  • R. Kothai Swamy Vivekanendha College of Pharmacy., Namakkal. Author

DOI:

https://doi.org/10.33974/ijrpst.v3i1.288

Abstract

The present study was aimed at developing and exploring the use of PPI dendrimers for delivery of anti-tuberculosis drug, Rifampicin (RMP). RMP was selected for incorporation into  dendrimers based on its antitubercular activity, short biological half-life and solubility characteristics.  For this study, poly(propyleneimine) dendritic architecture was loaded with Rifampicin.Various physicochemical  and  physiological  parameters  like  UV,  FT-IR,  TEM,  DSC, zeta potential, drug  entrapment and drug release of  formulations were determined. By constructing drug  release kinetics, the release mechanism followed was a non fickian diffusion. In this, the system was found to have increased their drug-loading capacity, reduced their drug release rate. Therefore the system was found to be suitable for prolonged delivery of  Rifampicin.

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Published

26-03-2024

Issue

Vol. 3 No. 1 (2022): Volume 3 Issue 1

Section

Research Article

License

Copyright (c) 2024 B. Valli Manalan, B. Arul , R. Kothai (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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This is an open-access article published in the International Journal of Research in Pharmaceutical Sciences and Technology (IJRPST) by Rubatosis Publications.

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How to Cite

Dendritic nanoparticulated carriers for the delivery of Rifampicin. (2024). International Journal of Research in Pharmaceutical Sciences and Technology, 3(1), Awaiting. https://doi.org/10.33974/ijrpst.v3i1.288