Dendritic nanoparticulated carriers for the delivery of Rifampicin

Abstract

The present study was aimed at developing and exploring the use of PPI dendrimers for delivery of anti-tuberculosis drug, Rifampicin (RMP). RMP was selected for incorporation into  dendrimers based on its antitubercular activity, short biological half-life and solubility characteristics.  For this study, poly(propyleneimine) dendritic architecture was loaded with Rifampicin.Various physicochemical  and  physiological  parameters  like  UV,  FT-IR,  TEM,  DSC, zeta potential, drug  entrapment and drug release of  formulations were determined. By constructing drug  release kinetics, the release mechanism followed was a non fickian diffusion. In this, the system was found to have increased their drug-loading capacity, reduced their drug release rate. Therefore the system was found to be suitable for prolonged delivery of  Rifampicin.