Molecular docking study of ferulic acid

Abstract

The main purpose of this study is the molecular docking of Ferulic acid with various enzymes such as 2PRG, 6COX, 1HD2, 2HCK, 2IOK, 2Y6W, 2YXJ, 4IEH, 5FDO, 3MWD, 3QNT. A molecular docking study was carried out by AutoDock 4. The results of the molecular docking study revealed that ferulic acid binds to the different enzymes. The results show the high affinity of ferulic acid with 2PRG, 6COX, 1HD2, 2HCK, 2IOK, 2Y6W, 2YXJ, 4IEH, 5FDO, 3MWD, 3QNT. The binding energy of the ferulic acid was compared with the known Anti-diabetic, anti-inflammatory, anticancer, antioxidant, Anti-apoptotic and Antihyperlipidemic standard drugs that inhibits 2PRG, 6COX, 1HD2, 2HCK, 2IOK, 2Y6W, 2YXJ, 4IEH, 5FDO, 3MWD, 3QNT enzyme. This study has tremendous scope in the pharmaceutical industry and biology for designing novel formulations for inhibiting different enzymes responsible for various diseases.