International Journal of Research in Pharmaceutical Sciences and Technology https://rubatosis.org/journals/index.php/ijrpst <p align="justify">Rubatosis Publication has launched its first online peer review scientific journal named International Journal of Research in Pharmaceutical Sciences and Technology (<strong>IJRPST, ISSN Online: 2581-9143</strong>). IJRPST will be published quarterly per year in January, April, July, and October. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences and Technology.</p> Rubatosis Publications en-US International Journal of Research in Pharmaceutical Sciences and Technology 2581-9143 Utilization of Lipids, Polymers by Modern Techniques for Innovative Pharmaceutical Formulations and Medical Devices https://rubatosis.org/journals/index.php/ijrpst/article/view/223 <p style="text-align: justify;">With advancing science and technology, new futuristic technologies have been upcoming that are having a greater impact on the pharmaceutical and biomedical fields. Many lipids and polymer of natural and synthetic origin have spread horizons enabling to reach in fabricating delivery systems for unmet medical needs. In this modern biomedicine era, we must outline and scrutiny the roles of these biomaterials and the modern technologies that are shaping up the advancing medicines. The real challenges in modulating, fine-tuning the biomaterials for their bioactive properties are vital for assessing the in-vivo performance of the developed systems. Therefore, the present review discusses the detailed analysis of the current research reported in the technologies of utilizing the lipids, polymers, and their role in delivering the drugs, genes, and designing advanced implantable medical devices. The scrutiny also focuses on key optimization tools, analytical methods, formulation, and biomedical techniques helpful in developing the solutions that can be administered different routes in different therapeutic indications.</p> M. Hima Bindu Buduru Gowthami Copyright (c) 2020 M. Hima Bindu, Buduru Gowthami https://creativecommons.org/licenses/by-nc-sa/4.0 2020-09-11 2020-09-11 2 1 07 11 10.33974/ijrpst.v2i1.223 Novel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs https://rubatosis.org/journals/index.php/ijrpst/article/view/231 <p>Oral administration is considered as major, convenient route among all other routes of delivery, owing to several benefits. But, the poor solubility or enzymatic/metabolic activity are the major concerns in developing a successful formulation. About 40% of approved drugs which are in the current market and 90% of new drug molecules in the developmental pipeline are hydrophobic in nature. The challenge to formulate insoluble drugs has met with various approaches to overcome the problems related to solubility, application of nanotechnology is one amongst them. The present review deals with various nanocarriers and technologies that are proven to be effective in enhancing the bioavilability of poorly soluble drugs.</p> Buduru Gowthami S.V. Gopala Krishna D. Subba Rao Copyright (c) 2020 Buduru Gowthami, S.V. Gopala Krishna, D. Subba Rao https://creativecommons.org/licenses/by-nc-sa/4.0 2020-09-17 2020-09-17 2 1 12 16 10.33974/ijrpst.v2i1.231 Formulation and in-vitro evaluation of ciprofloxacin HCl floating matrix tablets https://rubatosis.org/journals/index.php/ijrpst/article/view/221 <p style="text-align: justify;">Oral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form. Oral route is considered most natural, uncomplicated, convenient and safe due to its ease of administration, patient acceptance and cost-effective manufacturing process. Gastroretentive drug delivery system was developed in pharmacy field and drug retention for a prolonged time has been achieved. The goal of this study was to formulate and in-vitro evaluate Ciprofloxacin HCl controlled release matrix floating tablets. Ciprofloxacin HCl floating matrix tablets were prepared by wet granulation method using two polymers such as HPMC K100M (hydrophilic polymer) and HPMC K15M. All the Evaluation parameters were within the acceptable limits. FTIR spectral analysis showed that there was no interaction between the drug and polymers. In-vitro dissolution study was carried out using USP dissolution test apparatus (paddle type) at 50 rpm. The test was carried out at 37 ± 0.5 0C in 900ml of the 0.1 N HCl buffer as the medium for eight hours. HPMC K100M shows a prolonged release when compared to HPMC K15M. These findings indicated that HPMC K100M can be used to develop novel gastroretentive controlled release drug delivery systems with the double advantage of controlled drug release at GIT pH. On comparing the major criteria in evaluation such as preformulation and in vitro drug release characteristics, the formulation F8 was selected as the best formulation, as it showed the drug content as 99±0.4% and swelling index ratio was 107.14, and in-vitro drug released 61.31±0.65% up to 8 hours. Results indicated that controlled Ciprofloxacin HCl release was directly proportional to the concentration of HPMC K100M and the release of drug followed non-Fickian diffusion. Based on all the above evaluation parameters it was concluded that the formulation batch F8 was found to be best formulation among the formulations F1 to F8 were prepared.</p> Dhulipalla Mounika I. Deepika Reddy K. Sai Chandralekha Kapu Harika Ramarao Nadendla Madhu Gudipati Copyright (c) 2020 Dhulipalla Mounika, I. Deepika Reddy, K. Sai Chandralekha, Kapu Harika, Ramarao Nadendla, Madhu Gudipati https://creativecommons.org/licenses/by-nc-sa/4.0 2020-08-30 2020-08-30 2 1 01 06 10.33974/ijrpst.v2i1.221