Formulation And Evaluation Of Mucoadhesive Buccal Films Of Enalapril Maleate

Abstract

Nowadays, extensive research is being carried out on the design and development of innovative drug delivery systems to improve safety, efficacy, and patient compliance. One such delivery system is the buccal film technology. The buccal mucosa is the best-suited site for local, as well as systemic delivery of drugs due to its physiological features. The goal of designing oral mucoadhesive buccal film for the anti-hypertensive drug Enalapril maleate is to increase the bioavailability. The formulation and evaluation of oral mucoadhesive buccal films of Enalapril maleate by solvent casting method. The Enalapril maleate is an anti-hypertensive drug that has high first-pass metabolism and shows 40-60% of bioavailability. Due to this condition, we took this drug to convert into films, which increases its bioavailability by decreasing the first mass metabolism. The preparation contains different formulations by using different polymers like Hydroxypropyl methylcellulose E 5 (HPMC), Hydroxypropyl methylcellulose E 50 (HPMC), and different plasticizers like PEG 400 & PG. The films of physicochemical evaluations like thickness (0. 14±0.004 mm), tensile strength 120.23 (g/cm2), % Drug content uniformity (97.6± 1.040%), surface pH (6.74±0.051), the swelling index is in the optimum range, folding endurance ( 175±2), and diffusion studies showed the optimum release of drug in the predetermined time.