Formulation and evaluation of herbal cream containing extracts of Murraya Koenigii & Cajanus Cajan

Abstract

Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care.  Herbal Plants such as Murraya Koenigii and Cajanus Cajan traditionally used for the treatment of wound healing activity. In the present investigation an attempt was made to prepare and evaluate the herbal cream comprising extracts of Murraya Koenigii and Cajanus Cajan. The herbal cream namely F1 to F6 were formulated from the ethanol extract of Murraya Koenigii and Cajanus Cajan. The extraction was done by the Soxhlation process. Formulation of Herbal Skin Cream for wound healing was successfully developed that met the relevant pharmaceutical characteristics. The prepared formulations are then evaluated for parameters like physical properties, pH, viscosity, Spreadability and stability of the formulated cream. The prepared formulations showed good Spreadability, no evidence of phase separation and good consistency during the study period. Stability parameters like visual appearance, nature, viscosity and pH of the formulations showed that there was no significant variation during the study period. The prepared formulations showed proper pH range that is approximately pH 6; it confirms the compatibility of the formulations with skin secretions. The creams were found to be stable during stability to ICH guidelines (40 ± 2 °C/ 75 ± 5 % RH) for 3 months. In-vitro Diffusion studied conducted on all the 6 formulations and F5 and F6 has shown good diffusion when compared to other formulations. Now it can be possible to develop creams containing herbal extracts and can be used as a barrier to protect skin.