Assessing role of lipid and polymer based delivery systems in inserts

Abstract

Majority of gynaecological, proctologic diseases were treated through rectal or vaginal delivery of medications, which can bypass the first pass metabolism and can produce required local effect. Inserts are evolutionary pharmaceutical dosageform that are semi solid at room temperature but upon insertion in cavities of humans, melt and release the drug localised. The inserts are advantageous since they can be placed at scare sites where blood perfusion is high that can enable for rapid absorption limiting many side effects. Ocular inserts represents the advanced technology in treating several ophthalmic diseases. Designing and development of optimum inserts is a challenge ever faced by Pharmaceutical researchers. In view of this, lipid and polymer based systems were additionally employed to improve the therapeutic efficiency of foresaid dosage forms. The review rationalises the importance of these inserts and their broad applications for multidisciplinary applications.