Formulation and evaluation of controlled - release floating tablets of pregabalin
DOI:
https://doi.org/10.33974/y8crbq37
Keywords:
Gastroretentive controlled release, Floating tablets, Hydroxypropyl methylcellulose, PregabalinAbstract
Gastroretentive controlled release systems aim to provide a steady release of medication to maintain therapeutic levels over an extended period. Developing an oral controlled release drug delivery system involves not only sustaining drug release but also prolonging the presence of the dosage form in the gastrointestinal tract until the drug is completely released at the desired time. The article's objective was to create and assess controlled-release floating tablets of pregabalin, a gabapentinoid drug, in the stomach to increase gastric residence time, thereby extending drug release and enhancing oral bioavailability. This was achieved by incorporating gelling polymers like Hydroxypropyl methylcellulose. Pregabalin (PGB) is commonly used to treat diabetic neuropathy, post-herpetic neuralgia, fibromyalgia, and partial-onset seizures. Pregabalin is primarily absorbed in the upper gastrointestinal tract and has a short half-life. Therefore, to reduce the dosing frequency of pregabalin a gastroretantive controlled release system. Hence it was decided to formulate and evaluate as controlled-release floating tablets of pregabalin using different combinations of HPMC K4M and HPMC K100LV.
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Copyright (c) 2024 B. Narasimha Rao, S. Sai Teja, S. Nelson Kumar., P. Gowtham Kumar Reddy, R. Hari Babu (Author)
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