Design, Development and Invitro Evaluation of Bilayer Tablets of Loratidine (IR) and Phenylephrine (SR)

Abstract

The present study was carried out to develop the Bilayer tablets of Phenylephrine as sustained release and Loratidine as immediate release component. Phenylephrine is a selective α1-adrenergic receptor agonist of the Phenylephrine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Loratadine is a second-generation peripheral histamine H1-receptor blocker used to treat allergies. In the present study the bilayer tablets of Phenylephrine (SR) and Loratidine (IR) was formulated and evaluated, percentage friability for all the formulations was below 1% indicating that the friability was within the range of standard specification. All the formulations showed post-compression parameters i.e. friability and drug content were within acceptable official IP limits. Various sustained release formulations were formulated with super disintegrant, polymer alone; and microcrystalline cellulose was used as diluents. The tablets were evaluated for Pharmacopeial and non-Pharmacopeial (industry specified) tests. Based on the results, F-8, F-4 were identified as better formulation amongst all formulations.