Analytical method development and validation for the estimation of Mirabegron in pure and its solid dosage form by UV spectrophotometric method

Authors

  • Badike Kuruva Suresh Department of Pharmaceutical chemistry, College of pharmaceutical sciences, Acharya Nagarjuna University, Guntur, India, 2019. Author
  • Nerusula Anusha Department of Pharmaceutical chemistry, College of pharmaceutical sciences, Acharya Nagarjuna University, Guntur, India, 2019. Author
  • Anne Boyina Sravani Department of Pharmaceutical chemistry, College of pharmaceutical sciences, Acharya Nagarjuna University, Guntur, India. Author

DOI:

https://doi.org/10.33974/ijrpst.v1i4.207

Abstract

A simple, economical, rapid, accurate, precise spectrophotometric method has been developed and validated according to ICH Guidlines for the Mirabegron as active pharmaceutical ingredient (API) by UV spectrophotometric method. The absorption maxima of Mirabegron was found to be at 249 nm wavelength using 1N Hcl as a solvent. Linearity range was found to be 3-15μg/ml, with the correlation coefficient being more than 0.999. The relative standard deviation was found to be < 2%. The percentage recovery was within the range of 98% -105%, indicating that there is no significant interference from the other ingredients present in the formulation. The method can be applied for the routine analysis of Mirabegron as API in pharmaceutical preparation.

Downloads

Download data is not yet available.
2-[2-Amino-1, 3-thiazol-4-yl]-N-[4-[2-{[[2R]-2-hydroxy-2-phenylethyl] amino} ethyl] phe-nyl]acetamide

Downloads

Published

21-07-2020

Issue

Vol. 1 No. 4 (2020): Volume 1 Issue 4

Section

Research Article

Categories

License

Copyright (c) 2020 Badike Kuruva Suresh, Nerusula Anusha, Anne Boyina Sravani (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

License Terms

This is an open-access article published in the International Journal of Research in Pharmaceutical Sciences and Technology (IJRPST) by Rubatosis Publications.

It is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, reproduction, and adaptation in any medium or format, provided the original author(s) and source are appropriately credited, a link to the license is provided, and any changes made are indicated.

To view a copy of this license, visit: https://creativecommons.org/licenses/by/4.0/

For any further queries or permissions beyond the scope of this license, please contact: editor@rubatosis.org

How to Cite

Analytical method development and validation for the estimation of Mirabegron in pure and its solid dosage form by UV spectrophotometric method. (2020). International Journal of Research in Pharmaceutical Sciences and Technology, 1(4), 146-150. https://doi.org/10.33974/ijrpst.v1i4.207