Novel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs

Authors

  • Buduru Gowthami Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Y.S.R. Cuddapah, Dist-516126, Andhra Pradesh, India. Author
  • S.V. Gopala Krishna Department of Pharmacognosy, Vagdevi College of Pharmacy and Research Centre, Brahmadevam, Nellore-524001, Andhra Pradesh, India. Author
  • D. Subba Rao Professor, Department of Chemical Engineering, J.N.T.U.A Ananthapuramu-515002, Andhra Pradesh, India. Author

DOI:

https://doi.org/10.33974/ijrpst.v2i1.231

Abstract

Oral administration is considered as major, convenient route among all other routes of delivery, owing to several benefits. But, the poor solubility or enzymatic/metabolic activity are the major concerns in developing a successful formulation. About 40% of approved drugs which are in the current market and 90% of new drug molecules in the developmental pipeline are hydrophobic in nature. The challenge to formulate insoluble drugs has met with various approaches to overcome the problems related to solubility, application of nanotechnology is one amongst them. The present review deals with various nanocarriers and technologies that are proven to be effective in enhancing the bioavilability of poorly soluble drugs.

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Some of the novel approaches to enhance the solubility and bioavailability of poorly soluble drugs

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Published

18-09-2020

Issue

Vol. 2 No. 1 (2020): Volume 2 Issue 1

Section

Review Article

License

Copyright (c) 2020 Buduru Gowthami, S.V. Gopala Krishna, D. Subba Rao (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

License Terms

This is an open-access article published in the International Journal of Research in Pharmaceutical Sciences and Technology (IJRPST) by Rubatosis Publications.

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How to Cite

Novel Approaches to Enhance Oral Bioavailability of Poorly Soluble Drugs. (2020). International Journal of Research in Pharmaceutical Sciences and Technology, 2(1), 12-16. https://doi.org/10.33974/ijrpst.v2i1.231