Formulation And Evaluation of Biodegradable Polymer Triple Layer Coated Multiparticulate System For Colon Targeting

Abstract

Abstract: In this present research work, the aim was to develop extended on targeted triple layer coated pellets filled capsule system of Curcumin for chronotherapeutic treatment of colon cancer. Materials and Methods: So triple layer coated pellets of curcumin were prepared using pH sensitive polymers by using fluidized bed dryer which was further filled into an empty gelatin capsule. The compatibility was assessed using FT-IR, DSC and SEM studies for pure drug, polymers and their physical mixtures. Results and Discussion: The prepared batches were subjected to physicochemical studies, drug content estimation, in-vitro drug release and stability studies. When FT-IR, DSC and SEM studies were performed, it was found that there was no interaction between curcumin and polymers used. The physicochemical properties of the entire prepared triple layer coated pellets batches were found to be in limits. The drug content percentage in the optimized formulation C9 was found to be 99.86± 0.02%. The optimized triple layer coated pellets-filled-capsule formulation C9 releases curcumin after a lag time of 3.14 ± 1.58, 17.48 ±0.03%, 68.72 ± 0.86%, and 98.46± 0.34% at the end of 2, 5, 9, and 12 h respectively. Conclusion: Thus, a novel colon targeted delivery system of curcumin was successfully developed by filling triple layer coated pellets into an empty gelatin capsule shell for targeting colon cancer treatment.