Utilization of Lipids, Polymers by Modern Techniques for Innovative Pharmaceutical Formulations and Medical Devices

  • M. Hima Bindu Department of Pharmaceutical Analysis, School of Pharmacy, Anurag Group of Institutions, Ghatkesar, Ranga Reddy Dist, 500088, Hyderabad, Telangana, India.
  • Buduru Gowthami Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet, Y.S.R. Cuddapah, Dist-516126, Andhra Pradesh, India.
Keywords: Lipids, Drug, Gene, Biomedical, Technology, Formulations, Polymers

Abstract

With advancing science and technology, new futuristic technologies have been upcoming that are having a greater impact on the pharmaceutical and biomedical fields. Many lipids and polymer of natural and synthetic origin have spread horizons enabling to reach in fabricating delivery systems for unmet medical needs. In this modern biomedicine era, we must outline and scrutiny the roles of these biomaterials and the modern technologies that are shaping up the advancing medicines. The real challenges in modulating, fine-tuning the biomaterials for their bioactive properties are vital for assessing the in-vivo performance of the developed systems. Therefore, the present review discusses the detailed analysis of the current research reported in the technologies of utilizing the lipids, polymers, and their role in delivering the drugs, genes, and designing advanced implantable medical devices. The scrutiny also focuses on key optimization tools, analytical methods, formulation, and biomedical techniques helpful in developing the solutions that can be administered different routes in different therapeutic indications.

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References

1. Kurakula, M., & Koteswara Rao, G. S. N. (2020). Moving polyvinyl pyrrolidone electrospun nanofibers and bioprinted scaffolds toward multidisciplinary biomedical applications. European Polymer Journal, 136, 109919. https://doi.org/10.1016/j.eurpolymj.2020.109919
2. Kurakula, M., Naveen, N. R., & Yadav, K. S. (2020). Formulations for Polymer Coatings. Polymer Coatings, 415–443. https://doi.org/10.1002/9781119655145.ch19.
3. Kurakula, M., & Rao, G. S. N. K. (2020). Type of Article: REVIEW Pharmaceutical Assessment of Polyvinylpyrrolidone (PVP): As Excipient from Conventional to Controlled Delivery Systems with a Spotlight on COVID-19 Inhibition. Journal of Drug Delivery Science and Technology, 102046
4. Kurakula, M., Sobahi, T. R., El-Helw, A., & Abdelaal, M. Y. (2014). Development and validation of a RP-HPLC method for assay of atorvastatin and its application in dissolution studies on thermosensitive hydrogel-based nanocrystals. Tropical Journal of Pharmaceutical Research, 13(10), 1681–1687. https://doi.org/10.4314/tjpr.v13i10.1
5. Abdelhady, S., Honsy, K. M., & Kurakula, M. (2015). Electro Spun- Nanofibrous Mats: A Modern Wound Dressing Matrix with a Potential of Drug Delivery and Therapeutics. Journal of Engineered Fibers and Fabrics, 10(4), 155892501501000. https://doi.org/10.1177/155892501501000411.
6. Kurakula, M., Srinivas, C., Kasturi, N., & Diwan, P. V. (2012). Formulation and Evaluation of Prednisolone Proliposomal Gel for Effective Topical Pharmacotherapy. International Journal of Pharmaceutical Sciences and Drug Research, 4(1), 35. www.ijpsdr.com
7. Alhakamy, N. A., Ahmed, O. A. A., Kurakula, M., Caruso, G., Caraci, F., Asfour, H. Z., Alfarsi, A., Eid, B. G., Mohamed, A. I., Alruwaili, N. K., Abdulaal, W. H., Fahmy, U. A., Alhadrami, H. A., Eldakhakhny, B. M., & Abdel-Naim, A. B. (2020). Chitosan-based microparticles enhance ellagic acid’s colon targeting and proapoptotic activity. Pharmaceutics, 12(7), 1–14. https://doi.org/10.3390/pharmaceutics12070652.
8. Kurakula, M., Ahmed, O. A. A., Fahmy, U. A., & Ahmed, T. A. (2016). Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. Journal of Liposome Research, 26(4), 288–296. https://doi.org/10.3109/08982104.2015.1117490
9. Venkatesh, M., & Mallesh, K. (2013). Self-Nano Emulsifying Drug Delivery System (Snedds) for Oral Delivery of Atorvastatin- Formulation and Bioavailability Studies. Journal of Drug Delivery and Therapeutics, 3(3), 131–140. https://doi.org/10.22270/jddt.v3i3.517
10. Kurakula, M., El-Helw, A. M., Sobahi, T. R., & Abdelaal, M. Y. (2015). Chitosan based atorvastatin nanocrystals: Effect of cationic charge on particle size, formulation stability, and in-vivo efficacy. International Journal of Nanomedicine, 10, 321–334. https://doi.org/10.2147/IJN.S77731
11. Naguib, G. H., Hassan, A. H., Al-Hazmi, F., Kurakula, M., Al-Dharrabh, A., Alkhalidi, H. M., Al-Ahdal, A. M., Hamed, M. T., & Pashley, D. H. (2017). Zein based magnesium oxide nanowires: Effect of anionic charge on size, release and stability. Digest Journal of Nanomaterials and Biostructures, 12(3), 741–749
12. Naguib, Ghada Hussein, Al-Hazmi, F. E., Kurakula, M., Abdulaziz Al-Dharrab, A., Mohamed Hosny, K., Mohammed Alkhalidi, H., Tharwat Hamed, M., Habiballah Hassan, A., Al-Mohammadi, A. M., Mohamed Alnowaiser, A., & Henry Pashley, D. (2018). Zein coated zinc oxide nanoparticles: Fabrication and antimicrobial evaluation as dental aid. International Journal of Pharmacology, 14(8), 1051–1059. https://doi.org/10.3923/ijp.2018.1051.105
13. Hosny, K. M., Aldawsari, H. M., Bahmdan, R. H., Sindi, A. M., Kurakula, M., Alrobaian, M. M., Aldryhim, A. Y., Alkhalidi, H. M., Bahmdan, H. H., Khallaf, R. A., & El Sisi, A. M. (2019). Preparation, Optimization, and Evaluation of Hyaluronic Acid-Based Hydrogel Loaded with Miconazole Self-Nanoemulsion for the Treatment of Oral Thrush. AAPS PharmSciTech, 20(7), 297. https://doi.org/10.1208/s12249-019-1496-7
14. Kurakula, M., & Raghavendra Naveen, N. (2020). In situ gel loaded with chitosan-coated simvastatin nanoparticles: Promising delivery for effective anti-proliferative activity against tongue carcinoma. Marine Drugs, 18(4), 201. https://doi.org/10.3390/md18040201
15. Murali, V. P., Fujiwara, T., Gallop, C., Wang, Y., Wilson, J. A., Atwill, M. T., Kurakula, M., & Bumgardner, J. D. (2020). Modified electrospun chitosan membranes for controlled release of simvastatin. International Journal of Pharmaceutics, 584, 119438. https://doi.org/10.1016/j.ijpharm.2020.119438
16. Ahmed, S., Sarim Imam, S., Zafar, A., Ali, A., Aqil, M., & Gull, A. (2016). In vitro and preclinical assessment of factorial design based nanoethosomes transgel formulation of an opioid analgesic. Artificial Cells, Nanomedicine and Biotechnology, 44(8), 1793–1802. https://doi.org/10.3109/21691401.2015.1102742
17. Vanitasagar, S., Srinivas, C., Subhashini, N. J. P., & Mallesh, K. (2012). Solid dispersion-a comparative study on the dissolution rate of aceclofenac. International Journal of Pharmacy and Pharmaceutical Sciences, 4(SUPPL.3), 274–278
18. Mohd, A. B., A, P. R., & Diwan, P. V. (2011a). Estimation of Prednisolone in Proliposomal formulation using RP HPLC method . Int. J. Res. Pharm. Biomed. Sci. 2011; 2: 663, 2(4), 1663–1669.
19. Mohd, A. B., A, P. R., & Diwan, P. V. (2011b). Estimation of Prednisolone in Proliposomal formulation using RP HPLC method . Int. J. Chem. Anal. Sci. 2011; 2: 1193, 2(4), 1663–1669.
20. Kurakula, M., Sobahi, T. R., El-Helw, A., & Abdelaal, M. Y. (2014). Development and validation of a RP-HPLC method for assay of atorvastatin and its application in dissolution studies on thermosensitive hydrogel-based nanocrystals. Tropical Journal of Pharmaceutical Research, 13(10), 1681–1687. https://doi.org/10.4314/tjpr.v13i10.16
21. Mallesh, K., Pasula, N., & Kumar Ranjith, C. P. (2012). Piroxicam proliposomal gel: a novel approach for tropical delivery. Journal of Pharmacy Research, 5(3), 1755–17
22. Hasnain, M. S., Nayak, A. K., Kurakula, M., & Hoda, M. N. (2020). Alginate nanoparticles in drug delivery. In Alginates in Drug Delivery (pp. 129–152). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00006-6
23. Abdelhady, S., Honsy, K. M., & Kurakula, M. (2015). Electro Spun- Nanofibrous Mats: A Modern Wound Dressing Matrix with a Potential of Drug Delivery and Therapeutics. Journal of Engineered Fibers and Fabrics, 10(4), 155892501501000. https://doi.org/10.1177/155892501501000411
24. Ahmed, O. A. A., Kurakula, M., Banjar, Z. M., Afouna, M. I., & Zidan, A. S. (2015). Quality by design coupled with near infrared in formulation of transdermal glimepiride liposomal films. Journal of Pharmaceutical Sciences, 104(6), 2062–2075. https://doi.org/10.1002/jps.24448
25. Alhakamy, N. A., Fahmy, U. A., Ahmed, O. A. A., Caruso, G., Caraci, F., Asfour, H. Z., Bakhrebah, M. A., Alomary, M. N., Abdulaal, W. H., Okbazghi, S. Z., Abdel-Naim, A. B., Eid, B. G., Aldawsari, H. M., Kurakula, M., & Mohamed, A. I. (2020). Chitosan coated microparticles enhance simvastatin colon targeting and pro-apoptotic activity. Marine Drugs, 18(4), 226. https://doi.org/10.3390/md18040226
26. Andleeb, A., & Yar, M. (2020). Application of Electrospun Materials in Industrial Applications. Electrospun Materials and Their Allied Applications, 215–242. https://doi.org/10.1002/9781119655039.ch8
27. Raghavendra Naveen, N., Kurakula, M., & Gowthami, B. (2020). Process optimization by response surface methodology for preparation and evaluation of methotrexate loaded chitosan nanoparticles. Materials Today: Proceedings. https://doi.org/10.1016/j.matpr.2020.01.491
28. Hasnain, M. S., Kiran, V., Kurakula, M., Rao, G. K., Tabish, M., & Nayak, A. K. (2020). Use of alginates for drug delivery in dentistry. In Alginates in Drug Delivery (pp. 387–404). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00015-7
29. Kurakula, M., & A. Ahmed, T. (2015). Co-Delivery of Atorvastatin Nanocrystals in PLGA based in situ Gel for Anti-Hyperlipidemic Efficacy. Current Drug Delivery, 13(2), 211–220. https://doi.org/10.2174/1567201813666151109102718
30. Naveen, N. R., Gopinath, C., & Kurakula, M. (2020). Okra-thioglycolic acid conjugate-synthesis, characterization, and evaluation as a mucoadhesive polymer. Processes, 8(3), 316. https://doi.org/10.3390/pr8030316
31. Kurakula, M., Rao, G. K., Kiran, V., Hasnain, M. S., & Nayak, A. K. (2020). Alginate-based hydrogel systems for drug releasing in wound healing. In Alginates in Drug Delivery (pp. 323–358). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00013-3
Published
11-09-2020
How to Cite
M. Hima Bindu, & Buduru Gowthami. (2020). Utilization of Lipids, Polymers by Modern Techniques for Innovative Pharmaceutical Formulations and Medical Devices . International Journal of Research in Pharmaceutical Sciences and Technology, 2(1), 07-11. https://doi.org/10.33974/ijrpst.v2i1.223
Section
Review Article