Advancements in nanostructure applications for the anticancer delivery of natural compounds
Keywords:
Nanomedicine, Natural compounds, Drug delivery, Nanostructures, Drug discovery, Anticancer, bioavailabilityAbstract
In drug design, compounds and extracts sourced from natural origins continue to play a crucial role, offering versatile interactions with enzymes, receptors, and metabolic pathways. Nanomedicine emerges as a powerful strategy for delivering these natural products, ensuring enhanced bioavailability, precise targeting, controlled release, and protection against physical alterations. The escalating interest in nano-delivery of natural compounds is evident through the growing number of scientific publications in this field. This review goes beyond merely showcasing successful examples of nano-delivery systems containing natural products; it aims to underscore the untapped potential within pharmaceutical and nutraceutical markets. Commencing with an exploration of plant-derived natural products and the methodologies employed for obtaining nanoformulations, this work delves into nanoparticulate drug delivery systems designed for the skin, central nervous, skeletal, cardiovascular systems, and diabetes. Despite notable advancements in preparing nanomedicines featuring specific dietary polyphenols, research focused on crude extracts or standardized fractions remains limited. Many plants possessing well-documented therapeutic properties, as listed in pharmacopoeias, are yet to fully harness the benefits of nanotechnological advancements. This review emphasizes the significance of developing adequate nanoformulations, with the potential to elevate certain plants from dietary supplements to pharmaceutical status by improving their bioavailability and efficacy. The exploration of untapped opportunities within the nexus of natural compounds and nanomedicine is vital for advancing drug delivery systems and expanding the repertoire of therapeutic options.
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