Harnessing Medicinal Plant Phytochemicals: Unveiling Pharmacological Potential and Novel Drug Delivery Strategies

Abstract

The significant progress in the field of anticancer research has spurred a growing interest in bioactive compounds with potential pharmacological properties. One well-established challenge in utilizing these natural bioactives is their inherent low solubility, leading to limited bioavailability and difficulties in formulating effective drug delivery strategies to specific target sites. In response to this challenge, this review provides a comprehensive overview of the latest advancements in the development of innovative drug delivery systems. Our analysis focuses on published data related to key plant secondary metabolites known for their potent anticancer potential, specifically the flavone, isoflavone, and stilbene groups, which have been successfully formulated using novel drug delivery systems. While the precise mechanisms of action for these selected natural compounds remain a subject of ongoing investigation, their anticancer effects are undeniable. Consequently, current research efforts are primarily dedicated to identifying these bioactive compounds' most effective delivery systems. Recent studies aim to elucidate the exact mechanisms of action and therapeutic benefits of these compounds and address the crucial issue of designing suitable natural compound delivery systems capable of efficiently transporting therapeutic doses to the intended target sites. This multifaceted approach underscores the ongoing commitment to advancing the field of anticancer research and improving the delivery of bioactive compounds with promising anticancer potential.